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4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol and afimoxifene

4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol has been researched along with afimoxifene in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19904 (36.36)18.7374
1990's1 (9.09)18.2507
2000's4 (36.36)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Halleux, C; Kallen, J; Keller, H; Renaud, J; Schlaeppi, JM; Stark, W1
Chao, EY; Collins, JL; Gaillard, S; Jones, DG; McDonnell, DP; Miller, AB; Orband-Miller, LA; Shearer, BG; Willson, TM; Zuercher, WJ1
Chao, EY; Collins, JL; Gaillard, S; McDonnell, DP; Miller, AB; Nolte, RT; Orband-Miller, LA; Wang, L; Willson, TM; Zuercher, WJ1
Devleeschouwer, N; Foster, AB; Jarman, M; Leclercq, G; Leung, OT; McCague, R1
Bagley, JR; Mokler, CM; Ruenitz, PC1
Bignon, E; Crastes de Paulet, A; Doré, JC; Gilbert, J; Miquel, JF; Ojasoo, T; Pons, M; Raynaud, JP1
Abecassis, J; Bignon, E; Crastes de Paulet, AC; Doré, JC; Gilbert, J; Miquel, JF; Ojasoo, T; Pons, M; Raynaud, JP1
Jordan, VC; Leclercq, G; McCague, R1
Hillard, EA; Huché, M; Jaouen, G; Pigeon, P; Salomon, E; Top, S; Vessières, A1
Curpan, RF; Jordan, VC; Lewis-Wambi, JS; Maximov, PY; Myers, CB1
Forman, BM; Huss, JM; Li, H; Yu, DD1

Other Studies

11 other study(ies) available for 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol and afimoxifene

ArticleYear
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
    Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14

    Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Division; Crystallography, X-Ray; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; HeLa Cells; Humans; Isoquinolines; Ligands; Models, Molecular; Radioligand Assay; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured

2003
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: Binding, Competitive; Estrogen Receptor beta; Fluorescence Resonance Energy Transfer; Genes, Reporter; Heat-Shock Proteins; HeLa Cells; Humans; Hydrazines; Ligands; Molecular Mimicry; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenols; Receptors, Estrogen; Structure-Activity Relationship; Transcription Factors

2005
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
    Bioorganic & medicinal chemistry letters, 2006, Feb-15, Volume: 16, Issue:4

    Topics: Binding Sites; Crystallography, X-Ray; Drug Design; Estrogen Receptor alpha; Humans; Ligands; Models, Molecular; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen

2006
Hydroxy derivatives of tamoxifen.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:10

    Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Female; Humans; Hydroxylation; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Tamoxifen

1985
Estrogenic and antiestrogenic activity of monophenolic analogues of tamoxifen, (Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N, N-dimethylethylamine.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:9

    Topics: Animals; Chemical Phenomena; Chemistry; Cytosol; Drug Stability; Estrogen Antagonists; Estrogens; Female; In Vitro Techniques; Magnetic Resonance Spectroscopy; Organ Size; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Uterus

1982
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation.
    Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3

    Topics: Acrylonitrile; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Humans; Multivariate Analysis; Protein Kinase C; Rats; Receptors, Estrogen; Stilbenes; Structure-Activity Relationship; Tumor Cells, Cultured

1992
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:9

    Topics: Animals; Breast Neoplasms; Cattle; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Cytosol; Female; Growth Inhibitors; Humans; Isomerism; Mice; Nitriles; Rats; Receptors, Estradiol; Structure-Activity Relationship; Terphenyl Compounds; Tumor Cells, Cultured

1989
Nonisomerizable analogues of (Z)- and (E)-4-hydroxytamoxifen. Synthesis and endocrinological properties of substituted diphenylbenzocycloheptenes.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Animals; Benzocycloheptenes; Breast Neoplasms; Cell Division; Chemical Phenomena; Chemistry; Female; Humans; Organ Size; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Uterus

1988
Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behavior.
    Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Electrochemistry; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Models, Molecular; Neoplasms, Hormone-Dependent; Organometallic Compounds; Ruthenium; Stereoisomerism; Structure-Activity Relationship; Tamoxifen

2005
Structure-function relationships of estrogenic triphenylethylenes related to endoxifen and 4-hydroxytamoxifen.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Estrogen Antagonists; Estrogens, Non-Steroidal; Ethylenes; Female; Humans; Models, Molecular; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Tamoxifen

2010
Identification of novel inverse agonists of estrogen-related receptors ERRγ and ERRβ.
    Bioorganic & medicinal chemistry, 2017, 03-01, Volume: 25, Issue:5

    Topics: Crystallography, X-Ray; Drug Inverse Agonism; Hydrogen Bonding; Inhibitory Concentration 50; Models, Molecular; Receptors, Estrogen; Structure-Activity Relationship

2017